SR 128 — Relative to California Neuroblastoma Awareness Day.

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SR128:v98#DOCUMENTBilland StartWHEREAS, EnrolledThere  August 14, 2026are Passedapproximately  IN 600 Senateto  August 13, 2026800 CALIFORNIAnew LEGISLATURE—cases 2025–2026of REGULARneuroblastoma SESSIONdiagnosed Senateeach Resolutionyear No.in the United States;

128Introducedand byWHEREAS, SenatorNeuroblastoma Pérez(Coauthors:accounts for about 8 to 10 percent of all childhood cancers and approximately 15 percent of childhood cancer deaths;

Senatorsand Arreguín,WHEREAS, Grove,Approximately McGuire,90 Rubio,percent andof Weber Pierson)August 03, 2026neuroblastoma Relativecases toare Californiadiagnosed Neuroblastomabefore Awarenessfive Day.years of age, with many cases occurring during infancy;

LEGISLATIVEand COUNSEL'SWHEREAS, DIGESTSRSymptoms 128,are Pérez.often nonspecific, which can delay diagnosis and treatment;

Digestand KeyBillWHEREAS, TextWHEREAS, Neuroblastoma isaccounts thefor mosta commondisproportionate cancershare inof infantspediatric andcancer thedeaths mostrelative commonto extracranialits solidincidence; tumor in childhood;

andWHEREAS,and ThereWHEREAS, areHigh-risk approximatelyneuroblastoma 600remains toone 800 new cases of neuroblastomathe diagnosedmost eachdifficult yearpediatric incancers theto Unitedtreat States;successfully;

andWHEREAS,and NeuroblastomaWHEREAS, accountsThe forestimated aboutfive-year 8survival torate 10for percentchildren ofwith allhigh-risk childhoodneuroblastoma cancersis and approximately 1563 percentpercent; of childhood cancer deaths;

andWHEREAS,and ApproximatelyWHEREAS, 90Treatment percentfor ofhigh-risk neuroblastoma casestypically arerequires diagnosedintensive beforemultimodal fivetherapy, yearsincluding ofchemotherapy, age,surgery, withradiation manytherapy, casesstem occurringcell duringtransplant, infancy;and immunotherapy;

andWHEREAS,and SymptomsWHEREAS, areSurvivors oftenmay nonspecific,experience whichsignificant canlifelong delayhealth diagnosiscomplications, including hearing loss, organ failure, and treatment;subsequent malignancies;

andWHEREAS,and NeuroblastomaWHEREAS, accountsChildren forwith aneuroblastoma disproportionateoften sharerequire ofprolonged pediatrictreatment cancerand deathsrepeated relativehospitalizations; to its incidence;

andWHEREAS,and High-riskWHEREAS, neuroblastomaAnti-GD2 remainsimmunotherapy onehas ofimproved theoutcomes mostfor difficultchildren pediatricwith cancershigh-risk toneuroblastoma; treat successfully;

andWHEREAS,and TheWHEREAS, estimatedEmerging five-yeartherapies, survivalincluding rateCAR-T forcell childrentreatments withtargeting high-risktumor neuroblastomaantigens issuch approximatelyas 63B7-H3, percent;are under active investigation for relapsed disease;

andWHEREAS,and TreatmentWHEREAS, forCalifornia high-riskis neuroblastomahome typicallyto requiresleading intensivepediatric multimodaloncology therapy,centers includingand chemotherapy,plays surgery,a radiationmajor therapy,role stemin celladvancing transplant,pediatric cancer research and immunotherapy;clinical care, including for neuroblastoma;

andWHEREAS,and SurvivorsWHEREAS, mayChildhood experiencecancers, significantincluding lifelongneuroblastoma, healthhistorically complications,receive includingsignificantly hearingless loss,research organfunding failure,compared andto subsequentadulthood malignancies;cancers;

andWHEREAS,and WHEREAS, Children with high-risk or relapsed neuroblastoma oftencontinue requireto prolongedface limited effective treatment options and repeateda hospitalizations;high risk of relapse, highlighting the need for continued research and therapeutic development;

andWHEREAS,and Anti-GD2WHEREAS, immunotherapyIncreased hasawareness improvedcan outcomessupport forearlier childrendiagnosis, withimprove high-riskoutcomes, neuroblastoma;and help drive investment in research and treatment advancements for pediatric cancers;

andWHEREAS,and EmergingWHEREAS, therapies,September includingis CAR-Trecognized cell treatments targeting tumor antigens such as B7-H3,Childhood areCancer underAwareness activeMonth investigationin forthe relapsedUnited disease;States;

andWHEREAS,now, therefore, be it Resolved by the Senate of the State of California, That the Senate designates September 3, 2026, as California isNeuroblastoma homeAwareness Day to leadingprovide pediatrica oncologydedicated centersopportunity to recognize the extraordinary resilience and playscourage aof majorchildren roleand infamilies advancingfighting pediatricthis cancerdisease researchand support the incredible effort of clinicians and clinicalresearchers care,working includingto foraddress neuroblastoma;this disease;

andWHEREAS,and Childhoodbe cancers,it includingfurther neuroblastoma,Resolved, historicallyThat receivethe significantlySecretary lessof researchthe fundingSenate comparedtransmit copies of this resolution to adulthoodthe cancers;author for appropriate distribution.

andWHEREAS, Children with high-risk or relapsed neuroblastoma continue to face limited effective treatment options and a high risk of relapse, highlighting the need for continued research and therapeutic development;

andWHEREAS, Increased awareness can support earlier diagnosis, improve outcomes, and help drive investment in research and treatment advancements for pediatric cancers;

andWHEREAS, September is recognized as Childhood Cancer Awareness Month in the United States;

now, therefore, be itResolved by the Senate of the State of California, That the Senate designates September 3, 2026, as California Neuroblastoma Awareness Day to provide a dedicated opportunity to recognize the extraordinary resilience and courage of children and families fighting this disease and support the incredible effort of clinicians and researchers working to address this disease;

and be it furtherResolved, That the Secretary of the Senate transmit copies of this resolution to the author for appropriate distribution.