United States 119th Congress Status: Passed House Bipartisan · 13 D · 6 R cosponsors

HR 3491 — DeOndra Dixon INCLUDE Project Act of 2025

Last action — Received in the Senate and Read twice and referred to the Committee on Health, Education, Labor, and Pensions.

  1. ✓
    Introduced
  2. ✓
    In Committee
  3. 3
    Passed House
  4. 4
    Passed Senate
  5. 5
    To Executive
  6. 6
    Enacted

This bill has passed the House. Introduced May 19, 2025. It now moves to the second chamber.

Next likely step: consideration and a floor vote in the Senate.

Odds of enactment

Moderate chance

Based on the sponsor, cosponsors, and committee posture, this bill has a moderate chance of becoming law.

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A statistical estimate from our own model of past outcomes — an insight, not a guarantee. Policymaking is volatile.

Prognosis

Advancing 54% · moderate confidence

  • Passed House

    Current position in the legislative process.

  • 19 sponsors

    1 primary, 18 co-sponsors signed on.

  • Bipartisan support

    Sponsored across 2 parties (13 D · 6 R) — cross-party backing.

Based on stage, sponsorship breadth, committee status, recorded votes, and cross-state momentum — a description of the observable signals, not a prediction.

In plain language

The bill aims to support inclusive strategies for individuals with disabilities in several areas.

This bill promotes initiatives focused on inclusivity for people with disabilities, particularly in health care and community access. It seeks to improve opportunities and support for these individuals across various sectors.

What this means for you
  • Workers: What this means for you: The bill may lead to enhanced workplace inclusivity initiatives, benefiting employees with disabilities.
  • Families: What this means for you: Families with members who have disabilities may see improved access to supportive services and opportunities.
  • Healthcare: What this means for you: Healthcare initiatives under this bill could provide better resources and support for individuals with disabilities.

Summary

DeOndra Dixon INCLUDE Project Act of 2025This bill provides statutory authority for a program of the National Institutes of Health (NIH) that carries out research and training relating to Down syndrome, including with respect to co-occurring conditions and improving the quality of life of affected individuals. The NIH must implement the program in consultation with relevant stakeholders and avoid duplicating existing NIH Down syndrome research.Biennially, the NIH must submit to Congress a report cataloging the research, including results that may be used in medical care or clinical research.

Bill Text

What Congress says this changes

H. Rept. 119-722

Published by the reporting committee Not generated — this is the committee's own “Changes in Existing Law Made by the Bill, as Reported”.

Text to be removed appears in [brackets]. Newly inserted text is italicised in the official report and cannot be marked in this plain-text rendition — read the official PDF ↗ for the authoritative formatting. 

changes in existing law made by 
the bill, as reported, are shown as follows (new matter is 
printed in italics and existing law in which no change is 
proposed is shown in roman):

 PUBLIC HEALTH SERVICE ACT

 * * * * * * *
TITLE IV--NATIONAL RESEARCH INSTITUTES

 * * * * * * *

Part B--General Provisions Respecting National Research Institutes

 * * * * * * *

SEC. 409K. DOWN SYNDROME RESEARCH.

 (a) In General.--The Director of NIH shall carry out a 
program of research, training, and investigation related to 
Down syndrome to be known as the ``INvestigation of Co-
occurring conditions across the Lifespan to Understand Down 
syndromE Project'' or the ``INCLUDE Project''.
 (b) Program Elements.--The program under subsection (a) shall 
include--
 (1) high-risk, high-reward research on the effects of 
 trisomy 21 on human development and health;
 (2) promoting research for participants with Down 
 syndrome across the lifespan, including cohort studies 
 to facilitate improved understanding of Down syndrome 
 and co-occurring conditions and development of new 
 interventions;
 (3) expanding the number of clinical trials that are 
 inclusive of, or expressly for, participants with Down 
 syndrome, including novel biomedical and 
 pharmacological interventions and other therapies 
 designed to promote or enhance activities of daily 
 living;
 (4) research on the biological mechanisms in 
 individuals with Down syndrome pertaining to 
 structural, functional, and behavioral anomalies and 
 dysfunction as well as stunted growth;
 (5) supporting research to improve diagnosis and 
 treatment of conditions co-occurring with Down 
 syndrome, including the identification of biomarkers 
 related to risk factors, diagnosis, and clinical 
 research and therapeutics;
 (6) research on the causes of increased prevalence, 
 and concurrent treatment, of co-occurring conditions, 
 such as Alzheimer's disease and related dementias and 
 autoimmunity, in individuals with Down syndrome; and
 (7) research, training, and investigation on 
 improving the quality of life of individuals with Down 
 syndrome and their families.
 (c) Coordination; Prioritizing Nonduplicative Research.--The 
Director of NIH shall ensure that--
 (1) the programs and activities of the institutes and 
 centers of the National Institutes of Health relating 
 to Down syndrome and co-occurring conditions are 
 coordinated, including through the Office of the 
 Director of NIH and priority-setting reviews conducted 
 pursuant to section 402(b)(3); and
 (2) such institutes and centers, prioritize, as 
 appropriate, Down syndrome research that does not 
 duplicate existing research activities of the National 
 Institutes of Health.
 (d) Consultation With Stakeholders.--In carrying out 
activities under this section, the Director of NIH shall, as 
appropriate and to the maximum extent feasible, consult with 
relevant stakeholders, including patient advocates, to ensure 
that such activities take into consideration the needs of 
individuals with Down syndrome.
 (e) Biennial Reports to Congress.--
 (1) In general.--The Director of NIH shall submit, on 
 a biennial basis, to the Committee on Energy and 
 Commerce and the Subcommittee on Labor, Health and 
 Human Services, Education, and Related Agencies of the 
 Committee on Appropriations of the House of 
 Representatives and the Committee on Health, Education, 
 Labor, and Pensions and the Subcommittee on Labor, 
 Health and Human Services, Education, and Related 
 Agencies of the Committee on Appropriations of the 
 Senate, a report that catalogs the research conducted 
 or supported under this section.
 (2) Contents.--Each report under paragraph (1) shall 
 include--
 (A) identification of the institute or center 
 involved;
 (B) a statement of whether the research is or 
 was being carried out directly by such 
 institute or center or by multiple institutes 
 and centers; and
 (C) identification of any resulting real-
 world evidence that is or may be used for 
 clinical research and medical care for patients 
 with Down syndrome.

 * * * * * * *

Source: H. Rept. 119-722 · govinfo

Action History

  1. Introduced in House

  2. Introduced in House

  3. Referred to the House Committee on Energy and Commerce.

  4. Committee Consideration and Mark-up Session Held

  5. Ordered to be Reported by the Yeas and Nays: 46 - 0.

  6. Reported by the Committee on Energy and Commerce. H. Rept. 119-722.

  7. Reported by the Committee on Energy and Commerce. H. Rept. 119-722.

  8. Placed on the Union Calendar, Calendar No. 627.

  9. Mr. Guthrie moved to suspend the rules and pass the bill.

  10. Considered under suspension of the rules. (consideration: CR H4649-4651)

  11. DEBATE - The House proceeded with forty minutes of debate on H.R. 3491.

  12. Passed/agreed to in House: On motion to suspend the rules and pass the bill Agreed to by voice vote. (text: CR H4649-4650)

  13. On motion to suspend the rules and pass the bill Agreed to by voice vote. (text: CR H4649-4650)

  14. Motion to reconsider laid on the table Agreed to without objection.

  15. Received in the Senate and Read twice and referred to the Committee on Health, Education, Labor, and Pensions.

Sponsors

Sponsorship breakdown

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1 sponsors · 18 co-sponsors · 528 not signed on

Sponsors (1)

Co-sponsors (18)

Not signed on (528)

528 members have not signed on to this bill.

Show all 528 →

"Not signed on" means a member has not sponsored or co-sponsored this bill — it does not imply opposition. Members flagged Voted No have a recorded No vote on this bill.

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Subjects

civil-rights healthcare labor education
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Frequently asked questions

What does HR 3491 do?
DeOndra Dixon INCLUDE Project Act of 2025This bill provides statutory authority for a program of the National Institutes of Health (NIH) that carries out research and training relating to Down syndrome, including with respect to co-occurring conditions and improving the quality of life of affected individuals. The NIH must implement the program in consultation with relevant stakeholders and avoid duplicating existing NIH Down syndrome research.Biennially, the NIH must submit to Congress a report cataloging the research, including results that may be used in medical care or clinical research.
Who sponsors HR 3491?
HR 3491 is sponsored by DeGette, Diana (Democratic), Hudson, Richard (Republican), DeLauro, Rosa L. (Democratic), Cole, Tom (Republican), Norton, Eleanor Holmes (Democratic), Stauber, Pete (Republican), Tonko, Paul (Democratic), Pettersen, Brittany (Democratic), Craig, Angie (Democratic), Crow, Jason (Democratic), Neguse, Joe (Democratic), Pocan, Mark (Democratic), Wagner, Ann (Republican), Ross, Deborah K. (Democratic), Kustoff, David (Republican), Subramanyam, Suhas (Democratic), Nadler, Jerrold (Democratic), Walkinshaw, James R. (Democratic), and Wittman, Robert J. (Republican).
What is the current status of HR 3491?
This bill has passed the House. Introduced May 19, 2025. It now moves to the second chamber.
Where can I track HR 3491?
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