South Carolina 2025-2026 Regular Session Status: In Committee

H 5397 — Controlled Substances

Last action — Member(s) request name added as sponsor: M.M.Smith

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  1. ✓
    Introduced
  2. 2
    In Committee
  3. 3
    Passed House
  4. 4
    Passed Senate
  5. 5
    To Executive
  6. 6
    Enacted

This bill is in committee in the House. Introduced March 24, 2026. It must pass committee before a floor vote.

Next likely step: a committee vote, then a floor vote in the House.

Prognosis

Stalled 16% · moderate confidence

Where this bill stands today.

Odds of enactment

Low

How often bills like it became law.

  • In Committee

    Current position in the legislative process.

  • 2 sponsors

    2 primary, 0 co-sponsors signed on.

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Summary

A BILL TO AMEND THE SOUTH CAROLINA CODE OF LAWS BY AMENDING SECTION 44-53-190, RELATING TO SCHEDULE I CONTROLLED SUBSTANCES, SO AS TO MAKE CERTAIN CHANGES REGARDING SUBSTITUTED TRYPTAMINES.

Bill Text

What changed in the latest version

168 added · 7 removed

Plain-language change summary

The recent changes to Bill H 5397 modify a section of South Carolina law that lists certain substances considered illegal drugs. Specifically, it updates the definitions and inclusion of several hallucinogenic substances known as substituted tryptamines. This matters because these changes could impact law enforcement practices and drug policy in the state, ensuring that the legislation is current with emerging substances that pose risks to public health.

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2025-2026 Bill 5397 Text of Previous Version (Mar.
24, 2026) - South Carolina Legislature Online South Carolina General Assembly126th Session, 2025-2026Bill 5397Indicates Matter StrickenIndicates New Matter(Text matches printed bills.
Document has been reformatted to meet World Wide Web specifications.)                 A bill   TO AMEND THE SOUTH CAROLINA CODE OF LAWS BY AMENDING SECTION 44-53-190, RELATING TO SCHEDULE I CONTROLLED SUBSTANCES, SO AS TO MAKE CERTAIN CHANGES REGARDING SUBSTITUTED TRYPTAMINES.
  Be it enacted by the General Assembly of the State of South Carolina:
  SECTION 1.  Section 44-53-190(D) of the S.C.
Code is amended to read:
      (D) Any material, compound, mixture, or preparation which contains any quantity of the following hallucinogenic substances, their salts, isomers, and salts of isomers, unless specifically excepted, whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
       1.
3,4-methylenedioxy amphetamine        2.
5-methoxy-3,4-methylenedioxy amphetamine        3.
3,4-methylenedioxymethamphetamine (MDMA)        4.
3,4,5-trimethoxy amphetamine        5.
Bufotenine        6.
Diethyltryptamine (DET)        7.
Dimethyltryptamine (DMT)        8.5.
4-methyl-2,5-dimethoxyamphetamine (STP)        9.6.
Ibogaine        10.7 Lysergic acid diethylamide (LSD)        11.8.
Marijuana        12.9.
Mescaline        13.10.
Peyote        14.11.
N-ethyl-3-piperidyl benzilate        15.12.
N-methyl-3-piperidyl benzilate        16.13.
Psilocybin        17.14.
Psilocyn        18.15.
Tetrahydrocannabinol (THC)        19.16.
2,5-dimethoxyamphetamine        20.17.
4-bromo-2,5-dimethoxyamphetamine        21.18.
4-Methoxyamphetamine        22.19.
Thiophene analog of phencyclidine        23.20.
Parahexyl        24.21.
Synthetic cannabinoids.-Any material, compound, mixture, or preparation that is not listed as a controlled substance in Schedule I through V, is not an FDA-approved drug, and contains any quantity of the following substances, their salts, isomers (whether optical, positional, or geometric), homologues, and salts of isomers and homologues, unless specifically excepted, whenever the existence of these salts, isomers, homologues, and salts of isomers and homologues is possible within the specific chemical designation:
           a.
Naphthoylindoles.
Any compound containing a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Including, but not limited to, JWH-015, JWH-018, JWH-019, JWH-073, JWH-081, JWH-122, JWH-200, JWH-210, JWH-398, AM-2201, WIN 55-212, AM-2201 (C1 analog), AM-1220.
           b.
Naphthylmethylindoles.
Any compound containing a 1H-indol-3-yl-(1-naphthyl)methane structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
           c.
Naphthoylpyrroles.
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Any compound containing a 3-(1-naphthoyl)pyrrole structure with substitution at the nitrogen atom of the pyrrole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the pyrrole ring to any extent and whether or not substituted in the naphthyl ring to any extent.
Including, but not limited to, JWH-307, JWH-370, JWH-176.
           d.
Naphthylmethylindenes.
Any compound containing a naphthylideneindene structure with substitution at the 3-position of the indene ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indene ring to any extent and whether or not substituted in the naphthyl ring to any extent.
           e.
Phenylacetylindoles.
Any compound containing a 3-phenylacetylindole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the phenyl ring to any extent.
Including, but not limited to, SR-18, RCS-8, JWH-203, JWH-250, JWH-251.
           f.
Cyclohexylphenols.
Any compound containing a 2-(3-hydroxycyclohexyl)phenol structure with substitution at the 5-position of the phenolic ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not substituted in the cyclohexyl ring to any extent.
Including, but not limited to, CP 47,497 (and homologues), cannabicyclohexanol, CP-55, 940.
           g.
Benzoylindoles.
Any compound containing a 3-(benzoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the phenyl ring to any extent.
Including, but not limited to, AM-694, Pravadoline (WIN 48,098), RCS-4, AM-630, AM-1241, AM-2233.
           h.
2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo [1,2,3-de]-1, 4-benzoxazin-6-yl]-1-napthalenylmethanone (WIN 55,212-2).
           i.
9-(hydroxymethyl)-6,6-dimethy l-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol 7370 (HU-210, HU-211).
           j.
Adamantoylindoles.
Any compound containing a 3-(1-adamantoyl)indole structure with substitution at the nitrogen atom of the indole ring by a alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the adamantyl ring system to any extent.
       22.
Substituted Tryptamines.
- Any material, compound, mixture, or preparation containing a 2-(1H-indol-3-yl)ethanamine, for example tryptamine, structure with or without mono- or di-substitution of the amine nitrogen with alkyl or alkenyl groups, or by inclusion of the amino nitrogen atom in a cyclic structure, whether or not substituted at the alpha position with an alkyl group, whether or not substituted on the indole ring to any extent with any alkyl, alkoxy, halo, hydroxyl, or acetoxy groups including, but not limited to:
           a.
Bufotenine;
           b.
DET (Diethyltryptamine);
           c.
DMT (Dimethyltryptamine);
           d.
Methyltryptamine;
           e.
5-MeO-DMT (5-Methoxy-N,N-Dimethyltryptamine);
           f.
5-MeO-DiPT (5-Methoxy-N,N-Diisopropyltryptamine);
           g.
MET (N-Methyl-N-ethyltryptamine);
           h.
DALT (N,N-Diallyltryptamine);
           i.
EiPT (N-Ethyl-N-isopropyltryptamine);
           j.
MiPT (N-Methyl-N-isopropyltryptamine);
           k.
5-Hydroxy-AMT (5-Hydroxy-alpha-methyltryptamine);
           l.
5-Hydroxy-N-methyltryptamine;
           m.
5-MeO-MiPT (5-Methoxy-N-methyl-N-isopropyltryptamine);
           n.
5-MeO-AMT (5-Methoxy-alpha-methyltryptamine);
           o.
5-Me-DMT (5-Methyl-N,N-dimethyltryptamine);
           p.
DiPT (N,N-Diisopropyltryptamine);
           q.
DPT (N,N-Dipropyltryptamine);
           r.
4-Hydroxy-DiPT (4-Hydroxy-N,N-diisopropyltryptamine);
           s.
5-MeO-DALT (5-Methoxy-N,N-Diallyltryptamine);
           t.
4-AcO-DMT (4-Acetoxy-N,N-dimethyltryptamine);
           u.
4-AcO-DiPT (4-Acetoxy-N,N-diisopropyltryptamine);
           v.
4-Hydroxy-DET (4-Hydroxy-N,N-diethyltryptamine);
           w.
4-Hydroxy-MET (4-Hydroxy-N-methyl-N-ethyltryptamine);
           x.
4-Hydroxy-MiPT (4-Hydroxy-N-methyl-N-isopropyltryptamine);
           y.
Methyl-alpha-ethyltryptamine;
           z.
Bromo-DALT (Bromo-N,N-diallyltryptamine);
           aa.
6-MeO-DMT (6-methoxy-N,N-dimethyltryptamine);
           bb.
5-OH-DMT (5-hydroxy-N,N-dimethyltryptamine);
           cc.
4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine).
  SECTION 2.  This act takes effect upon approval by the Governor.
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Action History

  1. Member(s) request name added as sponsor: M.M.Smith

  2. Referred to Committee on Judiciary

  3. Introduced and read first time

Sponsors

Sponsorship breakdown

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2 sponsors · 0 co-sponsors · 168 not signed on

Sponsors (2)

Co-sponsors (0)

None.

Not signed on (168)

168 members have not signed on to this bill.

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"Not signed on" means a member has not sponsored or co-sponsored this bill — it does not imply opposition. Members flagged Voted No have a recorded No vote on this bill.

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Frequently asked questions

What does H 5397 do?
A BILL TO AMEND THE SOUTH CAROLINA CODE OF LAWS BY AMENDING SECTION 44-53-190, RELATING TO SCHEDULE I CONTROLLED SUBSTANCES, SO AS TO MAKE CERTAIN CHANGES REGARDING SUBSTITUTED TRYPTAMINES.
Who sponsors H 5397?
H 5397 is sponsored by Representative Thomas E. "Tommy" Pope and Representative Marvin "Mark" Smith.
What is the current status of H 5397?
This bill is in committee in the House. Introduced March 24, 2026. It must pass committee before a floor vote.
Where can I track H 5397?
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